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And now for one more controversial submit… 🙂 A preprint of the Yale Akiko Iwasaki/Harlan Krumholz post-vaccination syndrome examine, “Immunological and Antigenic Signatures Related to Continual Sicknesses after COVID-19 Vaccination“, was just lately revealed.
Over 100 million individuals have engaged in vaccine trials worldwide…
(Picture by torstensimon from Pixabay )
Vaccine blogs draw plenty of warmth, however please notice that feedback touting conspiracy theories is not going to be allowed. Nor will feedback asserting that vaccines are accountable for every part beneath the solar. We’re not happening these rabbit holes once more.
Vaccine Research
Let’s get some examine proof out of the best way.
The truth that coronavirus vaccinations cut back the chance of lengthy COVID will not be doubtful. A meta-analysis of 25 research involving 14 million individuals concluded that 1 and a pair of vaccinations have been related to a 15% and 24% discount within the threat of coming down with lengthy COVID after a coronavirus an infection.
Neither is the truth that the coronavirus vaccines saved many lives doubtful. The world over, over 100 million individuals have participated in coronavirus vaccine trials. By Nov 2022, the U.S. has administered greater than 655 million doses to US residents, which, a modeling examine estimated, saved greater than 18 million further hospitalizations, greater than 3 million further deaths, and $1.15 trillion in further medical prices.
Nor ought to anybody query whether or not the vaccines additionally brought about issues, at occasions. The authors famous that uncommon antagonistic occasions, equivalent to myocarditis and pericarditis, thrombosis and thrombocytopenia, Guillain–Barre syndrome, transverse myelitis, and Bell’s Palsy have been related to vaccination.
How hardly ever did these situations crop up? Very, very hardly ever (myocarditis (often minor) 4.8 circumstances per 1 million doses; Bell’s Palsy – 25.3 per 1,000,000 doses; thrombosis – 0.21 circumstances per 1 million; Guillian-Barre – 32.4 per 100,000 person-years (Jansennen vaccine); transverse myelitis – 1.82 circumstances per million vaccine doses). The truth that vaccine research picked these uncommon situations up in any respect is a testomony to how efficient they have been at choosing up ailments the medical system is monitoring. In each case, having a coronavirus an infection locations an individual vulnerable to contracting these ailments greater than a coronavirus vaccination does.
Then again, it’s clear that the research have been very poor at choosing up individuals with what’s now referred to as “post-vaccination syndrome” (PVS). PVS seems, symptom-wise, to be a useless ringer for ME/CFS and lengthy COVID (train intolerance, extreme fatigue, numbness, mind fog, neuropathy, insomnia, palpitations, myalgia, tinnitus or buzzing in ears, headache, burning sensations, and dizziness). The truth that PVS hasn’t proven up in post-vaccine research solely demonstrates that you could’t discover what you’re not in search of.
An enormous query that might be troublesome to reply – given how many individuals have been additionally contaminated with the virus – is how many individuals have post-vaccination syndrome.
Immune System Tweak
The authors instructed a number of ways in which tweaking the immune system to guard in opposition to the virus can, in some individuals, trigger signs an identical to the virus.
The totally different parts present in vaccines, “mRNA, lipid nanoparticles, and adenoviral vectors”, may very well be activating the sample recognition receptors, which set off the early, or innate, immune response. The spike protein might set off signs. Referencing Dr. Patterson’s work, the authors famous that non-classical monocytes of some individuals with PVS had been proven to include the S protein. Plus, in animals the protein has been proven to cross the blood-brain barrier. Lastly, the immune responses triggered by the vaccine might produce an autoimmune response.
The Examine
The small examine took a deep dive into the “immunophenotypic profiles” (circulating immune cell populations, antibody responses, circulating immune modulator ranges, spike protein) in 42 individuals with PVS and 22 wholesome controls who had been vaccinated.
One potential confounder was that checks revealed that 27/42 individuals with post-vaccination syndrome had additionally been uncovered to the coronavirus sooner or later. Most PVS sufferers, nonetheless, reported reacting to the vaccine inside 10 days, so it’s assumed that their response was to the vaccine. A number of the immune findings might, nonetheless, consequence from a coronavirus an infection.
Outcomes
Not surprisingly the examine discovered that the well being standing of the PVS sufferers was “far beneath” the conventional they usually reported a decrease high quality of life. The commonest signs have been extreme fatigue (85%), tingling and numbness (80%), train intolerance (80%), mind fog (77.5%), problem concentrating or focusing (72.5%), hassle falling or staying asleep (70%), neuropathy (70%), muscle aches (70%), nervousness (65%), tinnitus (60%) and burning sensations (57.5%).
As soon as once more, B-cells weren’t getting activated. May ME/CFS, lengthy COVID, and PVS begin right here?
Unswitched Reminiscence B-Cells
The discovering that the proportions of unswitched reminiscence B cells (US reminiscence B cells; CD19+/CD27+/IgD+) have been considerably increased (p= 0.02) within the PVS sufferers was intriguing given related findings in ME/CFS.
Nath’s intramural examine discovered increased ranges of naïve (immature) B-cells and decreased numbers of mature reminiscence B-cells. Nath proposed that the excessive ranges of immature B-cells would possibly represent “the first defect” in ME/CFS, doubtlessly resulting in immune exhaustion and activation of innate immune responses.
So far, the T and B-cell findings in ME/CFS level to issues with vitality manufacturing. May ME/CFS be forward of the sport relating to T and B-cell failings?
T-Cell Exhaustion
The “decreased CD4+ T cell subsets in circulation and an elevated proportion of TNFα+ CD8 T cells”, plus increased ranges of exhausted CD8 (cytotoxic) T-cells, once more appears harking back to findings in ME/CFS and lengthy COVID. The elevated percentages of the cytotoxic T-cell subset means that the T-cell exhaustion is pushed by persistent activation by a virus or items of a virus.
Elevated Classical Monocytes
Diminished cDC2 cells and elevated ranges of non-classical monocytes recommend an impaired immune response to the virus, persistent irritation, significantly within the blood vessels, and an elevated threat of autoimmunity. The activation of classical monocytes performs a key position in Bruce Patterson’s speculation of lengthy COVID-19.
A Bruce Patterson Interlude
Bruce Patterson MD raised plenty of curiosity – and controversy – when he went on a social media tour in 2020/2021 claiming that he knew what brought about lengthy COVID, had developed checks to diagnose it, and a protocol to deal with it. Time will inform how proper Patterson was about all that, nevertheless it needs to be famous that his speculation – that an overactive innate immune system that’s making an attempt to compensate for T and B-cell deficiencies – is similar to what Nath and others have proposed.
Bruce Patterson MD (with Well being Bio) has begun a big lengthy COVID medical trial.
Patterson discovered atypically long-lived classical monocytes carrying the spike protein in lengthy COVID, and really early on proclaimed that post-vaccination syndrome was occurring. Patterson additionally highlighted herpesvirus reactivation and asserted that different pathogens (Lyme illness) have been additionally changing into reactivated. Patterson’s Aug 2024 paper used machine studying and cytokine findings to distinguish persistent Lyme illness from lengthy COVID.
Two weeks in the past, Patterson and his firm, HealthBio (previously IncellDx) put their cash the place their mouth was after they introduced they’d begun a large section III, 32-week randomized, 252-patient, double-blind, placebo-controlled, multicenter trial assessing the effectiveness of Patterson’s protocol (Selzentry (maraviroc) and Lipitor (atorvastatin)) in lengthy COVID.
Patterson will not be throughout social media anymore—drawing consideration and criticism for his provocative findings—however HealthBio is definitely not holding again about how earth-shattering it believes its findings are. The HealthBio web site states that “HealthBio has found the foundation trigger and resolution for diagnosing and treating persistent inflammatory ailments,” together with ME/CFS, post-treatment Lyme illness, and fibromyalgia.
EBV Reactivation Discovered
The GIST
- A preprint of the Yale Akiko Iwasaki/Harlan Krumholz post-vaccination syndrome examine, “Immunological and Antigenic Signatures Related to Continual Sicknesses after COVID-19 Vaccination“, was just lately revealed.
- Vaccine blogs draw plenty of warmth, however please notice that feedback touting conspiracy theories is not going to be allowed. Nor will feedback asserting that vaccines are accountable for every part beneath the solar.
- Over 100 million individuals have participated in vaccine research worldwide and the outcomes are fairly clear. Coronavirus vaccines have saved many lives, prevented many hospitalizations, and are protecting in opposition to lengthy COVID. In very uncommon circumstances, they improve the chance of growing some ailments, however coronavirus infections improve the chance of contracting these ailments extra.
- The vaccine research, nonetheless, have been very poor at choosing up indicators of what’s now referred to as “post-vaccination syndrome” or PVS whose signs are an in depth match to these present in lengthy COVID, ME/CFS and fibromyalgia. We merely don’t know the way many individuals have PVS.
- This 42-person examine delved deep into the immune programs of individuals with PVS. A number of findings—an absence of B-cell maturation, T-cell exhaustion, elevated classical monocyte ranges, Epstein-Barr virus (EBV) reactivation, and a persistent spike protein—appeared to mimick findings in lengthy COVID and/or ME/CFS.
- A acquainted theme of innate immune system activation making an attempt to compensate for the failure of the T and B cells to combat off the virus appeared to emerge.
- Whereas not all PVS sufferers had the spike protein, in some circumstances, it was nonetheless current over two years after an infection – suggesting the protein should still be tweaking their immune programs. A lot work is underway higher to grasp viral persistence’s position in lengthy COVID.
- Larger reactivity to Epstein-Barr virus (EBV) proteins related to cytotoxic T-cell activation instructed that EBV reactivation was tweaking the PVS sufferers’ immune programs as properly. Due to this fact, both of the viruses may very well be inflicting or contributing to the signs present in lengthy COVID-19.
- The classical monocyte discovering appeared to echo Bruce Patterson’s findings of two years in the past. Patterson and his firm Well being Bio just lately started a big section III medical trial of their strategy to lengthy COVID.
- A machine studying strategy, which discovered that hormones and neuropeptides related to stress response, pain-detecting nerves, and immune activation have been related to PVS, introduced extra similarities to ME/CFS, FM, and lengthy COVID.
- The Yale group obtained warmth from traditionalists and vaccine conspiracists. Traditionalists didn’t need to hear about PVS proper now, given RFK Jr.’s ascension to a management place, and vaccine conspiracy theorists bought a lift from Elon Musk, who, although lengthy COVID predated the coronavirus vaccines, tweeted that “they’re lastly admitting “Lengthy COVID” is simply vaccine damage.”
- Whereas small, this examine was excellent news for anybody with post-coronavirus vaccination syndrome or any form of post-viral vaccination syndrome (PVS).
- Getting outcomes just like these present in lengthy COVID and/or ME/CFS instructed that discovering a solution to these ailments will even assist individuals with PVS
“A robust and versatile know-how for analyzing antibody responses” serum epitope repertoire evaluation (SERA) assessed which viruses the contributors had been uncovered to. The evaluation indicated that the post-vaccination syndrome (PVS) sufferers weren’t sick as a result of they’d been uncovered to extra pathogens.
Subsequent, the researchers need to see if the PVS sufferers’ immune programs have been extra activated in opposition to proteins discovered on EBV’s outer envelope. EBV makes use of each these proteins (EBV gp42, EBV gp350) to bore into and infect B-cells. Elevated antibody ranges in opposition to each of those proteins instructed the PVS sufferers have been preventing off EBV reactivation. (Vaccines to dam EBV gp350 are being studied.)
A constructive correlation between PVS sufferers with larger antibody reactivity to gp42 and elevated TNFα-producing CD8+ T-cells instructed that EBV reactivation was certainly turning on the T-cells (which have been changing into exhausted).
Spike Protein Exhibits Up
A variety of consideration is being centered on the spike protein (purple appendages)…
The coronavirus vaccines introduce the spike protein – the a part of the coronavirus that infects cells – in numerous methods. mRNA vaccines (Pfizer-BioNTech and Moderna) ship directions to the immune system to provide it. The Johnson and Johnson vaccine modifies the virus in order that it tells cells to provide the protein and Novovax straight introduces the spike protein.
There are numerous causes vaccine makers have centered on this specific protein: it permits the coronavirus to contaminate the cells, it’s simple to focus on, antibodies to it might probably neutralize the virus, and many others.
The authors said that maybe essentially the most notable discovering was elevated ranges of spike (S1 and full-length S) as much as 709 days after vaccination amongst a subset with PVS, even in these with no proof of detectable SARS-CoV-2 an infection. This was a bit shocking as a result of, by 14 days, the spike protein is often undetectable, nevertheless it does match with Bruce Patterson’s findings of the spike protein in non-classical monocytes lengthy after vaccination (or an infection).
In fact, the concept the long-term persistence of the spike protein would possibly set off signs through irritation and blood clotting in long-term COVID-19 will not be new.
As we’ve seen in lengthy COVID – not everybody with PVS had excessive S1 ranges. Nonetheless, as a gaggle, the PVS group had increased S1 ranges than a long-COVID group the researchers examined.
Predicting Submit-Vaccination Syndrome
A machine studying strategy instructed that the hormones (hypothalamus, pituitary glands) and neuropeptides related to stress response and pain-detecting nerves (oxytocin, neurotensin, ꞵ endorphin, melanocyte-stimulating hormones (MSH), substance P) have been negatively related to PVS.
Indicators of EBV reactivation and immune activation (anti-EBV gp42 IgG titers, MMP1 ranges, and TNFɑ+ CD8 T cells) have been positively related to the PVS.
Controversy
Doing a post-vaccination syndrome examine was certain to upset each traditionalists and conspiracy theorists…
Figuring out that the findings could be controversial (and misinterpreted), the authors emphasised the small examine measurement and the necessity for replication and validation. Iwasaki even famous that it was too early to distinguish significant outcomes from random fluctuations within the information. Some lambasted Iwasaki and Krumholz for even doing the examine, given the anti-vaccine motion and, now, RFK Jr.’s ascension to a management place.
Dr. Iwasaki referred to as it “the primary form of glimpse” at what was happening in post-vaccination syndrome, and pledged extra research to come back.
The misinterpretations and over-reactions got here shortly. Elon Musk did his credibility no good when, ignoring the truth that lengthy COVID appeared lengthy earlier than the vaccines have been obtainable, he advised his 218 million followers on X.com that “they’re lastly admitting “Lengthy COVID” is simply vaccine damage“. STAT Information reported that Iwasaki stated, “Oh, no! Actually?”, when advised of that.
This isn’t the primary time that Musk has been method off with COVID-19. Musk referred to the coronavirus as a “particular type of the widespread chilly”, said that “the coronavirus panic is dumb”, and predicted that there could be “near zero new circumstances” within the US by the top of April 2020. He additionally guess podcaster Sam Harris $1 million that the US wouldn’t exceed 35,000 COVID-19 circumstances. (As of Feb 2025, over 110 million coronavirus circumstances had been confirmed (and the full is probably going a lot larger).)
Conclusion
Whereas small, this examine was excellent news for anybody with post-coronavirus vaccination syndrome or any form of post-viral vaccination syndrome (PVS). PVS has been a difficulty in ME/CFS for many years, nevertheless it took over 100 million American vaccinations for a number of researchers to begin taking it severely. (The subsequent vaccine research—when and wherever they happen—ought to embody PVS of their assessments.) Fortunately, this examine got here from a extremely revered Yale analysis group led by Akiko Iwasaki.
It was excellent to see findings broadly just like these present in lengthy COVID and ME/CFS pop up. The elevated variety of unswitched B-cells and classical monocytes, the T-cell exhaustion and EBV reactivation all appeared to parallel findings in lengthy COVID and/or ME/CFS. A well-recognized theme of innate immune system compensation for a failure of the T and B-cells to combat off the virus appeared to point out itself.
Discovering proof of the spike protein in some circumstances two years post-infection in some PVS sufferers additionally match with long-COVID findings suggesting that items of the virus should still be activating the immune system, and an excessive amount of work is investigating this risk.
The classical monocyte discovering additionally appeared to echo Bruce Patterson’s findings of two years in the past. It additionally delivered to thoughts Grisham’s surprising discovering suggesting that monocytes play a key position in ME/CFS. Patterson’s firm HealthBio just lately started a big multicenter trial of Patterson’s protocol in lengthy COVID.
A machine studying strategy, which discovered that hormones and neuropeptides related to stress response, pain-detecting nerves, and immune activation have been related to PVS, introduced extra similarities to ME/CFS, FM, and lengthy COVID.
Getting outcomes just like these present in lengthy COVID and/or ME/CFS instructed that discovering a solution to these ailments will even assist individuals with PVS. Whereas greater research are wanted, the PVS analysis subject bought itself off to begin with this one.
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